In the list below, the numbers indicate lecture topics. Click on one, and you'll get the slides we showed in class. Lectures are assigned on dates listed in the syllabus. More than one lecture may be assigned on a given date. The dates in the list below tell you when the lecture slides were added to this website. Under each lecture topic, the open circles indicate additional readings. Some of these are clickable too and take you to the reading itself, in pdf format. You'll need a pdf reader such as Adobe Acrobat Reader or xpdf. If the reading is under copyright, you'll be asked for a username and password. If you didn't get this in class, then email one of us.
For students who want to dip into the professional literature, there are links labeled "optional".
Probability [16 January 2024 16:40:12.]
Partitioning variance [11 January 2024 19:26:38.]
Genomes and variation [19 January 2024 23:26:50.]
Rogers. 2024. The confusing vocabulary of population genetics.
Gillespie sections 1.0-1.3
Random mating [23 January 2024 16:24:07.]
Decay of heterozygosity [04 January 2024 19:11:21.]
Mutation versus drift [25 January 2024 16:11:48.]
Describing DNA sequence variation [31 January 2024 01:06:11.]
Gene genealogies [06 February 2023 22:28:05.]
Gillespie section 2.6
Python [08 February 2024 15:16:28.]
Site frequency spectrum [08 February 2024 21:54:27.]
Mismatch distribution and population growth [09 October 2015 02:56:42.]
Population growth [09 February 2023 17:30:58.]
The neutral theory of molecular evolution [20 February 2024 16:59:51.]
Selection [23 February 2024 21:55:20.]
Gillespie sections 3.0-3.3
Not quite enough selection Not quite enough selection (or perhaps a bit too much).
When bad things happen to good genes: mutation vs selection [27 February 2024 16:22:15.]
Gillespie section 3.4
Genetic load [27 February 2024 16:22:27.]
Fixation of mutations [28 February 2024 23:02:58.]
Gillespie sections 3.9-3.10
Neutral evolution at two loci [30 March 2020 16:53:34.]
Selection two loci [30 March 2020 16:55:04.]
Why LD helps us find selective sweeps [13 March 2020 23:19:51.]
Inbreeding [24 March 2020 19:20:35.]
Inbreeding, drift, and fitness [19 March 2024 15:59:13.]
Population structure [05 April 2020 21:52:46.]
Gillespie, section 5.5.
Rogers, 2020. Geographic population structure.
Population structure part 2 [25 March 2024 22:35:18.]
Detecting natural selection with genomic data [26 March 2024 22:20:51.]
Hejase et al 2020 Summary statistics to gene trees: methods for inferring positive selection.
Genetic draft [25 March 2024 22:45:30.]
Population history from whole genomes [02 April 2024 14:45:27.]
Archaic genes in modern humans [04 April 2024 16:09:01.]
Mendez et al, 2012 Global Genetic Variation at OAS1 Provides Evidence of Archaic Admixture in Melanesian Populations.
Vernot and Akey, 2014 Resurrecting surviving Neandertal lineages from modern human genomes.
QTs 1: genes and environment [08 April 2024 22:05:19.]
QTs 2: heritability [12 April 2024 16:35:31.]
QTs 3: response to selection [08 April 2024 22:04:34.]
Gillespie, section 6.2
Trait mapping [16 April 2024 23:03:44.]
Tam et al. 2019 Benefits and limitations of genome-wide association studies.
Uffelmann et al 2021 Genome-wide association studies.
Missing heritability: trait prediction and prospects for personalized medicine
Manolio et al. 2009 Finding the missing heritability of complex diseases
Massarat et al. 2023 Human pangenome supports analysis of complex genomic regions
Liao et al 2023 A draft human pangenome reference.
Povysil et al. 2019 Rare-variant collapsing analyses for complex traits: guidelines and applications.
Choi et al. 2020 Tutorial: a guide to performing polygenic risk score analyses.
Genome-Wide Association Studies (GWAS) [18 April 2024 20:59:34.]
Evolution of quantitative traits [24 April 2024 00:17:12.]